Viral RNA Patterns and High Viral Load Reliably Define Oropharynx Carcinomas with Active HPV16 Involvement
نویسندگان
چکیده
منابع مشابه
Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines.
HPV-related HNSCC generally have a better prognosis than HPV-negative HNSCC. However, a subgroup of HPV-positive tumors with poor prognosis has been recognized, particularly related to smoking, EGFR overexpression and chromosomal instability. Viral integration into the host genome might contribute to carcinogenesis, as is shown for cervical carcinomas. Therefore, all HPV16-positive HNSCC cell l...
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Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antigen. Although they do not appear to exert immunological pressure in vivo, these CD8 cells are not cla...
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Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated. Materials and...
متن کاملProspective study of HPV16 viral load and risk of in situ and invasive squamous cervical cancer.
BACKGROUND A strong association has been shown between high viral DNA load (VL) of human papillomavirus (HPV) type 16 and risk for cervical cancer in situ (CIS). However, little data is available for the significance of VL in invasive squamous cell carcinoma (SCC). METHODS In 2 nested case-control studies among women participating in cervical screening, with a cytologically normal first smear...
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Thank you for submitting your manuscript on the identification of DUB function in the TYMV protease for consideration by The EMBO Journal. Three referees have now provided their comments, which are copied below. As you will see, the referees appreciate that your study (for the most part convincingly) establishes TYMV 98K as a bona fide new example of a viral DUB enzyme, although a few open ques...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-11-3934